Visualisation Compte Rendu
Geoffrey BOILAY
14 septembre, 2023
Contexte
Chaque enregistrement correpond à un patient qui a réalisé une ponction lombère (LCR). Une LCR n’étant pas réalisée pour des raisons mineurs, tous les patients de la BDD ont présentés des problèmes cognitifs.
Objectif
L’objectif de l’étude est d’analyser l’association entre différents biomarqueurs sanguins et les protéines Abeta et tau, marqueurs de la maladie d’Alzheimer.
Analyses des variables
Dimension de la BDD
## [1] "Nombre d'observations : 1804"## [1] "Nombre de variables : 180"Variables socio-démographique
Age
Summary
Boxplot
Histogramme
## $breaks
## [1] 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95
##
## $counts
## [1] 1 0 1 2 3 12 38 105 170 237 382 364 289 159 40 1
##
## $density
## [1] 0.0001108647 0.0000000000 0.0001108647 0.0002217295 0.0003325942
## [6] 0.0013303769 0.0042128603 0.0116407982 0.0188470067 0.0262749446
## [11] 0.0423503326 0.0403547672 0.0320399113 0.0176274945 0.0044345898
## [16] 0.0001108647
##
## $mids
## [1] 17.5 22.5 27.5 32.5 37.5 42.5 47.5 52.5 57.5 62.5 67.5 72.5 77.5 82.5 87.5
## [16] 92.5
##
## $xname
## [1] "d"
##
## $equidist
## [1] TRUE
##
## attr(,"class")
## [1] "histogram"Sexe
Distribution
Niveau d’étude
Légende
1 = non scolarisé
2 = primaire sans diplôme
3 = certificat d’études
4 = secondaire (collège/CAP/brevet)
5 = secondaire (BEP/lycée)
6 = baccalauréat
7 = études supérieures
8 = non renseigné
Modalités normales
Recodage des Modalités
Barplot
Statut Marital
Distribution
Barplot
## [1] "Jamais marié" "Divorcé" "Marié / en couple"
## [4] "Veuf"
Nombre d’enfants
Modalités normales
Recodage des Modalités
Barplot
Mode de vie
Distribution
Barplot
Comportement de santé
Tabac
Distribution
Barplot
Alcool
Distribution
Barplot
Variables de santé
IMC
Summary
Boxplot
Histogramme
Découpage
Barplot
## [1] "Insuffisance pondérale" "Corpulence normale"
## [3] "Obésité modérée" "Obésité morbide ou massive"
## [5] "Obésité sévère" "Surpoids"
Fréquence Cardiaque
Summary
Boxplot
Histogramme
Distribution
Tension Artérielle Systolique
Summary
Boxplot
Histogramme
Tension Artérielle Diastolique
Summary
Boxplot
Histogramme
Hyper Tension Artérielle
Distribution
Barplot
Dyslipidemie
Distribution
Barplot
Les traitements
Table médicament restant
## Warning: Using one column matrices in `filter()` was deprecated in dplyr 1.1.0.
## ℹ Please use one dimensional logical vectors instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.MMSE
Score MMSE le plus proche de la PL
Summary
Boxplot
Histogramme
Découpage
Barplot
Dernier Score MMSE réalisé (en j)
Summary
Boxplot
Histogramme
Différence entre le premier et dernier Score MMSE (en j)
Summary
Boxplot
Histogramme
Nombre de Score MMSE avant la PL
Summary
Boxplot
Histogramme
Nombre de Score MMSE après la PL
Summary
Boxplot
Histogramme
APOE
Distribution
Distribution présence E4
Barplot
Diagnostique clinique
Légende
1 = MA
2 = MCI amnésique
3 = MCI autre
4= Démence mixte
5 = Démence vasculaire
6 = DFT
7 = Lewy
8 = Atrophie corticale postérieure
9 = Démence alcoolique
10 = Aphasie progressive primaire
11 = Trouble psychiatrique
12 = VIH
13 = NSP
14 = Autre
Distribution
Barplot
Biomarqueur de la MA
Abeta42
Distribution
Barplot
Standardisation
Standardisation du logarithme de la variable multipliée par -1 en prenant en compte les différentes périodes
Boxplot
Histogramme
Abeta40
Distribution
Standardisation
Standardisation du logarithme de la variable multipliée par -1 en prenant en compte les différentes périodes
Boxplot
Histogramme
Tau
Distribution
Barplot
Standardisation
Standardisation du logarithme de la variable en prenant en compte les différentes périodes
Boxplot
Histogramme
Ptau
Distribution
Barplot
Standardisation
Standardisation du logarithme de la variable en prenant en compte les différentes périodes
Boxplot
Histogramme
Corrélation
Pearson
Spearman
Biomarqueur sanguin
Cholesterol Total (g/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `cholesterol_total.reg`.Cholesterol hdl (g/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `cholesterol_hdl.reg`.Cholesterol ldl (g/l)
Summary
Boxplot
Histogramme
Glucose à jeun (mmol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `glucose_jeun.reg`.Triglycerides (g/l)
Summary
Boxplot
Histogramme
Corrélation
Biomarqueur sanguin + age
Pearson
Spearman
Biomarqueur sanguin + mmse + apoe
Pearson
Spearman
Biomarqueur sanguin + Biomarqueur de la MA
Pearson
Spearman
Autres biomarqueurs
Folates (nmol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `folates.reg`.Vitamine B12 (pmol/l)
Summary
Boxplot
Histogramme
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `vitamine_b12.reg`.Vitamine D (nmol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `vitamine_d.reg`.Proteines (g/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `proteines.reg`.TSH (mu/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `tsh.reg`.Uree (mmol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `uree.reg`.Creatinine (umol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `creatinine.reg`.Calcium (mmol/l)
Summary
Boxplot
Histogramme
Découpage
## Warning: Unknown or uninitialised column: `calcium.reg`.## integer(0)Corrélation
Autres marqueurs + age
Pearson
Spearman
Autres marqueurs + mmse + apoe
Pearson
Spearman
Autres marqueurs + Biomarqueur sanguin
Pearson
Spearman
Etude d’association
Abeta42
Tableau de fréquence
| abeta42 faible (N=502) | abeta42 normal (N=474) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.259 (8.141) | 67.977 (9.341) | 69.665 (8.893) | |
| - Range | 47.000 - 89.000 | 42.000 - 89.000 | 42.000 - 89.000 | |
| Sexe | 0.064 | |||
| - Femme | 287 (57.2%) | 243 (51.3%) | 530 (54.3%) | |
| - Homme | 215 (42.8%) | 231 (48.7%) | 446 (45.7%) | |
| Glucose | 0.782 | |||
| - Mean (SD) | 5.739 (1.546) | 5.769 (1.828) | 5.754 (1.688) | |
| - Range | 0.720 - 18.500 | 0.920 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.709 | |||
| - Mean (SD) | 0.948 (0.333) | 0.956 (0.346) | 0.951 (0.339) | |
| - Range | 0.380 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.002 | |||
| - Mean (SD) | 2.167 (0.509) | 2.064 (0.507) | 2.117 (0.510) | |
| - Range | 1.030 - 6.640 | 0.820 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | 0.105 | |||
| - Mean (SD) | 0.601 (0.167) | 0.584 (0.152) | 0.593 (0.160) | |
| - Range | 0.210 - 1.590 | 0.270 - 1.380 | 0.210 - 1.590 | |
| Cholesterol ldl | < 0.001 | |||
| - Mean (SD) | 1.370 (0.404) | 1.269 (0.381) | 1.321 (0.396) | |
| - Range | 0.360 - 2.970 | 0.200 - 2.630 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 195 (38.8%) | 345 (72.8%) | 540 (55.3%) | |
| - 1 | 230 (45.8%) | 122 (25.7%) | 352 (36.1%) | |
| - 2 | 77 (15.3%) | 7 (1.5%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.106 (5.435) | 23.951 (4.458) | 22.488 (5.181) | |
| - Range | 4.000 - 30.000 | 5.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.215 | |||
| - 0 | 420 (83.7%) | 410 (86.5%) | 830 (85.0%) | |
| - 1 | 82 (16.3%) | 64 (13.5%) | 146 (15.0%) | |
| Traitement Diabete | 0.170 | |||
| - 0 | 472 (94.0%) | 435 (91.8%) | 907 (92.9%) | |
| - 1 | 30 (6.0%) | 39 (8.2%) | 69 (7.1%) | |
| Niveau d’étude | 0.126 | |||
| - N-Miss | 31 | 35 | 66 | |
| - études supérieurs | 174 (36.9%) | 166 (37.8%) | 340 (37.4%) | |
| - niveau études intermédiaires | 159 (33.8%) | 169 (38.5%) | 328 (36.0%) | |
| - niveau études mineurs | 138 (29.3%) | 104 (23.7%) | 242 (26.6%) |
Abeta42 en Catégorie
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.26 | 1.10, 1.44 | <0.001 |
| age | 1.59 | 1.37, 1.85 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.25 | 1.08, 1.44 | 0.002 |
| age | 1.59 | 1.37, 1.84 | <0.001 |
| sexe | 1.12 | 0.86, 1.47 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.05 | 0.78, 1.42 | 0.7 |
| niveau études mineurs | 1.28 | 0.92, 1.77 | 0.14 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.18 | 1.02, 1.37 | 0.028 |
| age | 1.64 | 1.40, 1.92 | <0.001 |
| sexe | 1.20 | 0.90, 1.59 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.94 | 0.68, 1.29 | 0.7 |
| niveau études mineurs | 1.21 | 0.86, 1.71 | 0.3 |
| apoe.reg2 | 3.39 | 2.70, 4.29 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.02, 1.38 | 0.025 |
| age | 1.64 | 1.40, 1.94 | <0.001 |
| sexe | 1.13 | 0.84, 1.51 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.75 | 0.51, 1.10 | 0.14 |
| apoe.reg2 | 3.21 | 2.55, 4.08 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.03, 1.39 | 0.022 |
| age | 1.63 | 1.39, 1.93 | <0.001 |
| sexe | 1.12 | 0.84, 1.51 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.74 | 0.51, 1.09 | 0.13 |
| apoe.reg2 | 3.21 | 2.55, 4.08 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 1.11 | 0.75, 1.65 | 0.6 |
| dia | 1.02 | 0.60, 1.71 | >0.9 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.18 | 1.01, 1.37 | 0.039 |
| age | 1.60 | 1.36, 1.89 | <0.001 |
| sexe | 1.08 | 0.80, 1.46 | 0.6 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.83 | 0.60, 1.16 | 0.3 |
| niveau études mineurs | 0.79 | 0.54, 1.17 | 0.2 |
| apoe.reg2 | 3.18 | 2.52, 4.04 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 1.13 | 0.76, 1.68 | 0.5 |
| dia | 1.08 | 0.64, 1.83 | 0.8 |
| imc | 0.96 | 0.92, 0.99 | 0.007 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.26 | 1.10, 1.44 | <0.001 | 1.25 | 1.08, 1.44 | 0.002 | 1.18 | 1.02, 1.37 | 0.028 | 1.19 | 1.02, 1.38 | 0.025 | 1.19 | 1.03, 1.39 | 0.022 | 1.18 | 1.01, 1.37 | 0.039 |
| age | 1.59 | 1.37, 1.85 | <0.001 | 1.59 | 1.37, 1.84 | <0.001 | 1.64 | 1.40, 1.92 | <0.001 | 1.64 | 1.40, 1.94 | <0.001 | 1.63 | 1.39, 1.93 | <0.001 | 1.60 | 1.36, 1.89 | <0.001 |
| sexe | 1.12 | 0.86, 1.47 | 0.4 | 1.20 | 0.90, 1.59 | 0.2 | 1.13 | 0.84, 1.51 | 0.4 | 1.12 | 0.84, 1.51 | 0.4 | 1.08 | 0.80, 1.46 | 0.6 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.05 | 0.78, 1.42 | 0.7 | 0.94 | 0.68, 1.29 | 0.7 | 0.80 | 0.58, 1.11 | 0.2 | 0.80 | 0.58, 1.11 | 0.2 | 0.83 | 0.60, 1.16 | 0.3 | |||
| niveau études mineurs | 1.28 | 0.92, 1.77 | 0.14 | 1.21 | 0.86, 1.71 | 0.3 | 0.75 | 0.51, 1.10 | 0.14 | 0.74 | 0.51, 1.09 | 0.13 | 0.79 | 0.54, 1.17 | 0.2 | |||
| apoe.reg2 | 3.39 | 2.70, 4.29 | <0.001 | 3.21 | 2.55, 4.08 | <0.001 | 3.21 | 2.55, 4.08 | <0.001 | 3.18 | 2.52, 4.04 | <0.001 | ||||||
| mmse | 0.90 | 0.87, 0.93 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | |||||||||
| ch | 1.11 | 0.75, 1.65 | 0.6 | 1.13 | 0.76, 1.68 | 0.5 | ||||||||||||
| dia | 1.02 | 0.60, 1.71 | >0.9 | 1.08 | 0.64, 1.83 | 0.8 | ||||||||||||
| imc | 0.96 | 0.92, 0.99 | 0.007 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.84, 1.07 | 0.4 |
| age | 1.55 | 1.34, 1.79 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.10 | 0.6 |
| age | 1.56 | 1.35, 1.80 | <0.001 |
| sexe | 1.30 | 1.00, 1.68 | 0.049 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.76, 1.35 | >0.9 |
| niveau études mineurs | 1.22 | 0.89, 1.68 | 0.2 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.83, 1.08 | 0.4 |
| age | 1.60 | 1.38, 1.87 | <0.001 |
| sexe | 1.32 | 1.00, 1.73 | 0.049 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.92 | 0.68, 1.26 | 0.6 |
| niveau études mineurs | 1.17 | 0.84, 1.65 | 0.4 |
| apoe.reg2 | 3.34 | 2.67, 4.20 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.83, 1.09 | 0.4 |
| age | 1.61 | 1.37, 1.89 | <0.001 |
| sexe | 1.25 | 0.94, 1.65 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.10 | 0.2 |
| niveau études mineurs | 0.69 | 0.47, 1.00 | 0.052 |
| apoe.reg2 | 3.22 | 2.57, 4.08 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.94 | 0.81, 1.10 | 0.5 |
| age | 1.60 | 1.36, 1.88 | <0.001 |
| sexe | 1.25 | 0.94, 1.65 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.79 | 0.58, 1.10 | 0.2 |
| niveau études mineurs | 0.68 | 0.46, 1.00 | 0.049 |
| apoe.reg2 | 3.22 | 2.56, 4.08 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| ch | 1.06 | 0.73, 1.56 | 0.8 |
| dia | 1.03 | 0.59, 1.80 | >0.9 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.98 | 0.84, 1.15 | 0.8 |
| age | 1.56 | 1.33, 1.84 | <0.001 |
| sexe | 1.21 | 0.91, 1.60 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.83 | 0.60, 1.14 | 0.2 |
| niveau études mineurs | 0.73 | 0.50, 1.08 | 0.11 |
| apoe.reg2 | 3.15 | 2.51, 4.00 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| ch | 1.10 | 0.75, 1.62 | 0.6 |
| dia | 1.04 | 0.59, 1.83 | 0.9 |
| imc | 0.95 | 0.92, 0.99 | 0.005 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.95 | 0.84, 1.07 | 0.4 | 0.97 | 0.85, 1.10 | 0.6 | 0.95 | 0.83, 1.08 | 0.4 | 0.95 | 0.83, 1.09 | 0.4 | 0.94 | 0.81, 1.10 | 0.5 | 0.98 | 0.84, 1.15 | 0.8 |
| age | 1.55 | 1.34, 1.79 | <0.001 | 1.56 | 1.35, 1.80 | <0.001 | 1.60 | 1.38, 1.87 | <0.001 | 1.61 | 1.37, 1.89 | <0.001 | 1.60 | 1.36, 1.88 | <0.001 | 1.56 | 1.33, 1.84 | <0.001 |
| sexe | 1.30 | 1.00, 1.68 | 0.049 | 1.32 | 1.00, 1.73 | 0.049 | 1.25 | 0.94, 1.65 | 0.13 | 1.25 | 0.94, 1.65 | 0.13 | 1.21 | 0.91, 1.60 | 0.2 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.01 | 0.76, 1.35 | >0.9 | 0.92 | 0.68, 1.26 | 0.6 | 0.80 | 0.58, 1.10 | 0.2 | 0.79 | 0.58, 1.10 | 0.2 | 0.83 | 0.60, 1.14 | 0.2 | |||
| niveau études mineurs | 1.22 | 0.89, 1.68 | 0.2 | 1.17 | 0.84, 1.65 | 0.4 | 0.69 | 0.47, 1.00 | 0.052 | 0.68 | 0.46, 1.00 | 0.049 | 0.73 | 0.50, 1.08 | 0.11 | |||
| apoe.reg2 | 3.34 | 2.67, 4.20 | <0.001 | 3.22 | 2.57, 4.08 | <0.001 | 3.22 | 2.56, 4.08 | <0.001 | 3.15 | 2.51, 4.00 | <0.001 | ||||||
| mmse | 0.89 | 0.86, 0.92 | <0.001 | 0.89 | 0.86, 0.92 | <0.001 | 0.89 | 0.86, 0.92 | <0.001 | |||||||||
| ch | 1.06 | 0.73, 1.56 | 0.8 | 1.10 | 0.75, 1.62 | 0.6 | ||||||||||||
| dia | 1.03 | 0.59, 1.80 | >0.9 | 1.04 | 0.59, 1.83 | 0.9 | ||||||||||||
| imc | 0.95 | 0.92, 0.99 | 0.005 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Abeta42 en Continue
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.10 | 0.04, 0.16 | 0.002 |
| age | 0.22 | 0.16, 0.29 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.11 | 0.05, 0.17 | <0.001 |
| age | 0.22 | 0.15, 0.29 | <0.001 |
| sexe | -0.07 | -0.19, 0.06 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.00 | -0.14, 0.14 | >0.9 |
| niveau études mineurs | 0.09 | -0.07, 0.24 | 0.3 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.020 |
| age | 0.21 | 0.15, 0.27 | <0.001 |
| sexe | -0.04 | -0.16, 0.08 | 0.5 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.19, 0.07 | 0.4 |
| niveau études mineurs | 0.05 | -0.09, 0.19 | 0.5 |
| apoe.reg2 | 0.64 | 0.55, 0.72 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.011 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.18, 0.04 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.034 |
| niveau études mineurs | -0.19 | -0.34, -0.05 | 0.009 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.012 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.18, 0.04 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.19 | -0.34, -0.04 | 0.010 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.01 | -0.22, 0.19 | 0.9 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.013 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.08 | -0.19, 0.03 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.25, 0.00 | 0.046 |
| niveau études mineurs | -0.18 | -0.33, -0.04 | 0.014 |
| apoe.reg2 | 0.58 | 0.50, 0.66 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.01 | -0.21, 0.19 | >0.9 |
| imc | 0.00 | -0.01, 0.00 | 0.10 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.10 | 0.04, 0.16 | 0.002 | 0.11 | 0.05, 0.17 | <0.001 | 0.07 | 0.01, 0.13 | 0.020 | 0.07 | 0.02, 0.13 | 0.011 | 0.07 | 0.02, 0.13 | 0.012 | 0.07 | 0.02, 0.13 | 0.013 |
| age | 0.22 | 0.16, 0.29 | <0.001 | 0.22 | 0.15, 0.29 | <0.001 | 0.21 | 0.15, 0.27 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.19, 0.06 | 0.3 | -0.04 | -0.16, 0.08 | 0.5 | -0.07 | -0.18, 0.04 | 0.2 | -0.07 | -0.18, 0.04 | 0.2 | -0.08 | -0.19, 0.03 | 0.2 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.00 | -0.14, 0.14 | >0.9 | -0.06 | -0.19, 0.07 | 0.4 | -0.13 | -0.26, -0.01 | 0.034 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.25, 0.00 | 0.046 | |||
| niveau études mineurs | 0.09 | -0.07, 0.24 | 0.3 | 0.05 | -0.09, 0.19 | 0.5 | -0.19 | -0.34, -0.05 | 0.009 | -0.19 | -0.34, -0.04 | 0.010 | -0.18 | -0.33, -0.04 | 0.014 | |||
| apoe.reg2 | 0.64 | 0.55, 0.72 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.58 | 0.50, 0.66 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | 0.00 | -0.15, 0.15 | >0.9 | 0.00 | -0.15, 0.15 | >0.9 | ||||||||||||
| dia | -0.01 | -0.22, 0.19 | 0.9 | -0.01 | -0.21, 0.19 | >0.9 | ||||||||||||
| imc | 0.00 | -0.01, 0.00 | 0.10 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.21 | 0.14, 0.28 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.21 | 0.14, 0.27 | <0.001 |
| sexe | -0.02 | -0.14, 0.10 | 0.8 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.16, 0.12 | 0.8 |
| niveau études mineurs | 0.05 | -0.11, 0.20 | 0.5 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.081 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.03 | -0.14, 0.09 | 0.6 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.19, 0.06 | 0.3 |
| niveau études mineurs | 0.02 | -0.12, 0.16 | 0.8 |
| apoe.reg2 | 0.63 | 0.55, 0.72 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.088 |
| age | 0.19 | 0.13, 0.24 | <0.001 |
| sexe | -0.06 | -0.16, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.24 | -0.39, -0.10 | 0.001 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.11 |
| age | 0.19 | 0.13, 0.25 | <0.001 |
| sexe | -0.06 | -0.16, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.24 | -0.39, -0.10 | 0.001 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.16, 0.14 | >0.9 |
| dia | 0.02 | -0.20, 0.23 | 0.9 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.15 |
| age | 0.18 | 0.12, 0.24 | <0.001 |
| sexe | -0.06 | -0.17, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.25, 0.00 | 0.046 |
| niveau études mineurs | -0.24 | -0.38, -0.09 | 0.002 |
| apoe.reg2 | 0.58 | 0.50, 0.66 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.15, 0.14 | >0.9 |
| dia | 0.02 | -0.20, 0.23 | 0.9 |
| imc | -0.01 | -0.01, 0.00 | 0.075 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 | -0.04 | -0.10, 0.02 | 0.2 | -0.05 | -0.11, 0.01 | 0.081 | -0.05 | -0.10, 0.01 | 0.088 | -0.05 | -0.11, 0.01 | 0.11 | -0.04 | -0.10, 0.02 | 0.15 |
| age | 0.21 | 0.14, 0.28 | <0.001 | 0.21 | 0.14, 0.27 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.19 | 0.13, 0.24 | <0.001 | 0.19 | 0.13, 0.25 | <0.001 | 0.18 | 0.12, 0.24 | <0.001 |
| sexe | -0.02 | -0.14, 0.10 | 0.8 | -0.03 | -0.14, 0.09 | 0.6 | -0.06 | -0.16, 0.05 | 0.3 | -0.06 | -0.16, 0.05 | 0.3 | -0.06 | -0.17, 0.05 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.16, 0.12 | 0.8 | -0.06 | -0.19, 0.06 | 0.3 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.25, 0.00 | 0.046 | |||
| niveau études mineurs | 0.05 | -0.11, 0.20 | 0.5 | 0.02 | -0.12, 0.16 | 0.8 | -0.24 | -0.39, -0.10 | 0.001 | -0.24 | -0.39, -0.10 | 0.001 | -0.24 | -0.38, -0.09 | 0.002 | |||
| apoe.reg2 | 0.63 | 0.55, 0.72 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.58 | 0.50, 0.66 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | -0.01 | -0.16, 0.14 | >0.9 | -0.01 | -0.15, 0.14 | >0.9 | ||||||||||||
| dia | 0.02 | -0.20, 0.23 | 0.9 | 0.02 | -0.20, 0.23 | 0.9 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.075 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Abeta40
Abeta40 en Continue
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.08 | 0.02, 0.14 | 0.011 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.00, 0.14 | 0.040 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.05, 0.22 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.16, 0.13 | 0.8 |
| niveau études mineurs | 0.01 | -0.15, 0.17 | 0.9 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.3 |
| age | 0.29 | 0.23, 0.36 | <0.001 |
| sexe | 0.10 | -0.03, 0.22 | 0.12 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.05 | -0.18, 0.09 | 0.5 |
| niveau études mineurs | 0.00 | -0.15, 0.15 | >0.9 |
| apoe.reg2 | 0.54 | 0.45, 0.63 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.3 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.09 | -0.04, 0.21 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.09 | -0.23, 0.05 | 0.2 |
| niveau études mineurs | -0.12 | -0.28, 0.04 | 0.14 |
| apoe.reg2 | 0.51 | 0.42, 0.60 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.08 | -0.04, 0.20 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.09 | -0.22, 0.05 | 0.2 |
| niveau études mineurs | -0.11 | -0.27, 0.05 | 0.2 |
| apoe.reg2 | 0.51 | 0.42, 0.60 | <0.001 |
| mmse | -0.02 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.22 | -0.45, 0.01 | 0.062 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.28 | 0.21, 0.35 | <0.001 |
| sexe | 0.07 | -0.06, 0.19 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.06 | 0.3 |
| niveau études mineurs | -0.09 | -0.25, 0.07 | 0.3 |
| apoe.reg2 | 0.50 | 0.41, 0.59 | <0.001 |
| mmse | -0.02 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.21 | -0.44, 0.02 | 0.077 |
| imc | -0.01 | -0.01, 0.00 | 0.007 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.08 | 0.02, 0.14 | 0.011 | 0.07 | 0.00, 0.14 | 0.040 | 0.03 | -0.03, 0.09 | 0.3 | 0.03 | -0.03, 0.09 | 0.3 | 0.03 | -0.03, 0.09 | 0.4 | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.30 | 0.23, 0.37 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.29 | 0.23, 0.36 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 | 0.28 | 0.21, 0.35 | <0.001 |
| sexe | 0.08 | -0.05, 0.22 | 0.2 | 0.10 | -0.03, 0.22 | 0.12 | 0.09 | -0.04, 0.21 | 0.2 | 0.08 | -0.04, 0.20 | 0.2 | 0.07 | -0.06, 0.19 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.16, 0.13 | 0.8 | -0.05 | -0.18, 0.09 | 0.5 | -0.09 | -0.23, 0.05 | 0.2 | -0.09 | -0.22, 0.05 | 0.2 | -0.07 | -0.21, 0.06 | 0.3 | |||
| niveau études mineurs | 0.01 | -0.15, 0.17 | 0.9 | 0.00 | -0.15, 0.15 | >0.9 | -0.12 | -0.28, 0.04 | 0.14 | -0.11 | -0.27, 0.05 | 0.2 | -0.09 | -0.25, 0.07 | 0.3 | |||
| apoe.reg2 | 0.54 | 0.45, 0.63 | <0.001 | 0.51 | 0.42, 0.60 | <0.001 | 0.51 | 0.42, 0.60 | <0.001 | 0.50 | 0.41, 0.59 | <0.001 | ||||||
| mmse | -0.03 | -0.04, -0.01 | <0.001 | -0.02 | -0.04, -0.01 | <0.001 | -0.02 | -0.04, -0.01 | <0.001 | |||||||||
| ch | 0.03 | -0.13, 0.20 | 0.7 | 0.03 | -0.13, 0.20 | 0.7 | ||||||||||||
| dia | -0.22 | -0.45, 0.01 | 0.062 | -0.21 | -0.44, 0.02 | 0.077 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.007 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 885"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.12 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.11, 0.02 | 0.2 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| sexe | 0.11 | -0.02, 0.24 | 0.11 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.17, 0.13 | 0.8 |
| niveau études mineurs | 0.00 | -0.16, 0.17 | >0.9 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.13 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| sexe | 0.09 | -0.03, 0.22 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.10 | 0.6 |
| niveau études mineurs | 0.01 | -0.14, 0.16 | 0.9 |
| apoe.reg2 | 0.52 | 0.43, 0.62 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.02 | 0.14 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.04, 0.21 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.07 | 0.3 |
| niveau études mineurs | -0.11 | -0.27, 0.05 | 0.2 |
| apoe.reg2 | 0.50 | 0.41, 0.59 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.10, 0.03 | 0.3 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.04, 0.20 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.07 | 0.3 |
| niveau études mineurs | -0.11 | -0.27, 0.06 | 0.2 |
| apoe.reg2 | 0.49 | 0.40, 0.59 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.14 | -0.38, 0.11 | 0.3 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.07 | -0.05, 0.19 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.20, 0.08 | 0.4 |
| niveau études mineurs | -0.09 | -0.26, 0.07 | 0.3 |
| apoe.reg2 | 0.49 | 0.39, 0.58 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.14 | -0.38, 0.11 | 0.3 |
| imc | -0.01 | -0.01, 0.00 | 0.007 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.12 | -0.04 | -0.11, 0.02 | 0.2 | -0.05 | -0.11, 0.01 | 0.13 | -0.05 | -0.11, 0.02 | 0.14 | -0.03 | -0.10, 0.03 | 0.3 | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.31 | 0.24, 0.38 | <0.001 | 0.31 | 0.24, 0.38 | <0.001 | 0.31 | 0.24, 0.38 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.11 | -0.02, 0.24 | 0.11 | 0.09 | -0.03, 0.22 | 0.13 | 0.08 | -0.04, 0.21 | 0.2 | 0.08 | -0.04, 0.20 | 0.2 | 0.07 | -0.05, 0.19 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.17, 0.13 | 0.8 | -0.04 | -0.17, 0.10 | 0.6 | -0.07 | -0.21, 0.07 | 0.3 | -0.07 | -0.21, 0.07 | 0.3 | -0.06 | -0.20, 0.08 | 0.4 | |||
| niveau études mineurs | 0.00 | -0.16, 0.17 | >0.9 | 0.01 | -0.14, 0.16 | 0.9 | -0.11 | -0.27, 0.05 | 0.2 | -0.11 | -0.27, 0.06 | 0.2 | -0.09 | -0.26, 0.07 | 0.3 | |||
| apoe.reg2 | 0.52 | 0.43, 0.62 | <0.001 | 0.50 | 0.41, 0.59 | <0.001 | 0.49 | 0.40, 0.59 | <0.001 | 0.49 | 0.39, 0.58 | <0.001 | ||||||
| mmse | -0.03 | -0.04, -0.01 | <0.001 | -0.03 | -0.04, -0.01 | <0.001 | -0.03 | -0.04, -0.01 | <0.001 | |||||||||
| ch | 0.03 | -0.13, 0.20 | 0.7 | 0.03 | -0.13, 0.20 | 0.7 | ||||||||||||
| dia | -0.14 | -0.38, 0.11 | 0.3 | -0.14 | -0.38, 0.11 | 0.3 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.007 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Tau
Tableau de fréquence
| tau elevé (N=543) | tau normal (N=433) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.516 (8.098) | 67.344 (9.301) | 69.665 (8.893) | |
| - Range | 49.000 - 89.000 | 42.000 - 88.000 | 42.000 - 89.000 | |
| Sexe | < 0.001 | |||
| - Femme | 322 (59.3%) | 208 (48.0%) | 530 (54.3%) | |
| - Homme | 221 (40.7%) | 225 (52.0%) | 446 (45.7%) | |
| Glucose | 0.732 | |||
| - Mean (SD) | 5.770 (1.723) | 5.733 (1.645) | 5.754 (1.688) | |
| - Range | 0.920 - 20.900 | 0.720 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.021 | |||
| - Mean (SD) | 0.929 (0.328) | 0.980 (0.351) | 0.951 (0.339) | |
| - Range | 0.340 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.061 | |||
| - Mean (SD) | 2.144 (0.510) | 2.083 (0.510) | 2.117 (0.510) | |
| - Range | 0.820 - 6.640 | 0.970 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | < 0.001 | |||
| - Mean (SD) | 0.610 (0.164) | 0.572 (0.153) | 0.593 (0.160) | |
| - Range | 0.210 - 1.100 | 0.220 - 1.590 | 0.210 - 1.590 | |
| Cholesterol ldl | 0.062 | |||
| - Mean (SD) | 1.342 (0.408) | 1.294 (0.379) | 1.321 (0.396) | |
| - Range | 0.200 - 2.730 | 0.480 - 2.970 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 240 (44.2%) | 300 (69.3%) | 540 (55.3%) | |
| - 1 | 242 (44.6%) | 110 (25.4%) | 352 (36.1%) | |
| - 2 | 61 (11.2%) | 23 (5.3%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.297 (5.439) | 23.982 (4.411) | 22.488 (5.181) | |
| - Range | 4.000 - 30.000 | 8.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.389 | |||
| - 0 | 457 (84.2%) | 373 (86.1%) | 830 (85.0%) | |
| - 1 | 86 (15.8%) | 60 (13.9%) | 146 (15.0%) | |
| Traitement Diabete | 0.727 | |||
| - 0 | 506 (93.2%) | 401 (92.6%) | 907 (92.9%) | |
| - 1 | 37 (6.8%) | 32 (7.4%) | 69 (7.1%) | |
| Niveau d’étude | 0.413 | |||
| - N-Miss | 37 | 29 | 66 | |
| - études supérieurs | 193 (38.1%) | 147 (36.4%) | 340 (37.4%) | |
| - niveau études intermédiaires | 173 (34.2%) | 155 (38.4%) | 328 (36.0%) | |
| - niveau études mineurs | 140 (27.7%) | 102 (25.2%) | 242 (26.6%) |
Tau en Catégorie
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.04, 1.36 | 0.012 |
| age | 1.82 | 1.57, 2.13 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.26 | 0.2 |
| age | 1.86 | 1.59, 2.17 | <0.001 |
| sexe | 1.69 | 1.28, 2.22 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.98 | 0.72, 1.32 | 0.9 |
| niveau études mineurs | 0.94 | 0.68, 1.31 | 0.7 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.21 | 0.5 |
| age | 1.89 | 1.61, 2.22 | <0.001 |
| sexe | 1.79 | 1.35, 2.38 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.90 | 0.65, 1.23 | 0.5 |
| niveau études mineurs | 0.88 | 0.63, 1.25 | 0.5 |
| apoe.reg2 | 2.23 | 1.80, 2.79 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.22 | 0.5 |
| age | 1.90 | 1.62, 2.25 | <0.001 |
| sexe | 1.71 | 1.28, 2.30 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.54, 1.04 | 0.089 |
| niveau études mineurs | 0.54 | 0.37, 0.78 | 0.001 |
| apoe.reg2 | 2.08 | 1.67, 2.60 | <0.001 |
| mmse | 0.90 | 0.87, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.22 | 0.5 |
| age | 1.90 | 1.61, 2.25 | <0.001 |
| sexe | 1.72 | 1.29, 2.31 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.54, 1.04 | 0.088 |
| niveau études mineurs | 0.53 | 0.36, 0.78 | 0.001 |
| apoe.reg2 | 2.08 | 1.67, 2.61 | <0.001 |
| mmse | 0.90 | 0.87, 0.92 | <0.001 |
| ch | 0.97 | 0.66, 1.43 | 0.9 |
| dia | 1.18 | 0.71, 1.97 | 0.5 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.02 | 0.88, 1.19 | 0.8 |
| age | 1.86 | 1.57, 2.21 | <0.001 |
| sexe | 1.64 | 1.22, 2.21 | 0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.57, 1.11 | 0.2 |
| niveau études mineurs | 0.58 | 0.39, 0.86 | 0.007 |
| apoe.reg2 | 2.05 | 1.64, 2.57 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 0.99 | 0.67, 1.46 | >0.9 |
| dia | 1.30 | 0.78, 2.20 | 0.3 |
| imc | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.19 | 1.04, 1.36 | 0.012 | 1.10 | 0.95, 1.26 | 0.2 | 1.05 | 0.91, 1.21 | 0.5 | 1.05 | 0.91, 1.22 | 0.5 | 1.05 | 0.91, 1.22 | 0.5 | 1.02 | 0.88, 1.19 | 0.8 |
| age | 1.82 | 1.57, 2.13 | <0.001 | 1.86 | 1.59, 2.17 | <0.001 | 1.89 | 1.61, 2.22 | <0.001 | 1.90 | 1.62, 2.25 | <0.001 | 1.90 | 1.61, 2.25 | <0.001 | 1.86 | 1.57, 2.21 | <0.001 |
| sexe | 1.69 | 1.28, 2.22 | <0.001 | 1.79 | 1.35, 2.38 | <0.001 | 1.71 | 1.28, 2.30 | <0.001 | 1.72 | 1.29, 2.31 | <0.001 | 1.64 | 1.22, 2.21 | 0.001 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.98 | 0.72, 1.32 | 0.9 | 0.90 | 0.65, 1.23 | 0.5 | 0.75 | 0.54, 1.04 | 0.089 | 0.75 | 0.54, 1.04 | 0.088 | 0.80 | 0.57, 1.11 | 0.2 | |||
| niveau études mineurs | 0.94 | 0.68, 1.31 | 0.7 | 0.88 | 0.63, 1.25 | 0.5 | 0.54 | 0.37, 0.78 | 0.001 | 0.53 | 0.36, 0.78 | 0.001 | 0.58 | 0.39, 0.86 | 0.007 | |||
| apoe.reg2 | 2.23 | 1.80, 2.79 | <0.001 | 2.08 | 1.67, 2.60 | <0.001 | 2.08 | 1.67, 2.61 | <0.001 | 2.05 | 1.64, 2.57 | <0.001 | ||||||
| mmse | 0.90 | 0.87, 0.92 | <0.001 | 0.90 | 0.87, 0.92 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | |||||||||
| ch | 0.97 | 0.66, 1.43 | 0.9 | 0.99 | 0.67, 1.46 | >0.9 | ||||||||||||
| dia | 1.18 | 0.71, 1.97 | 0.5 | 1.30 | 0.78, 2.20 | 0.3 | ||||||||||||
| imc | 0.93 | 0.90, 0.96 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.93 | 0.82, 1.05 | 0.2 |
| age | 1.80 | 1.56, 2.10 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.98 | 0.86, 1.12 | 0.8 |
| age | 1.86 | 1.60, 2.16 | <0.001 |
| sexe | 1.71 | 1.31, 2.23 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.94 | 0.70, 1.27 | 0.7 |
| niveau études mineurs | 0.88 | 0.63, 1.22 | 0.4 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.11 | 0.6 |
| age | 1.88 | 1.61, 2.20 | <0.001 |
| sexe | 1.74 | 1.32, 2.28 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.88 | 0.65, 1.20 | 0.4 |
| niveau études mineurs | 0.84 | 0.60, 1.17 | 0.3 |
| apoe.reg2 | 2.19 | 1.77, 2.72 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.12 | 0.7 |
| age | 1.90 | 1.62, 2.23 | <0.001 |
| sexe | 1.66 | 1.26, 2.20 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.76 | 0.55, 1.04 | 0.083 |
| niveau études mineurs | 0.49 | 0.33, 0.71 | <0.001 |
| apoe.reg2 | 2.07 | 1.66, 2.58 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.96 | 0.83, 1.12 | 0.6 |
| age | 1.89 | 1.61, 2.23 | <0.001 |
| sexe | 1.66 | 1.26, 2.20 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.55, 1.04 | 0.082 |
| niveau études mineurs | 0.49 | 0.33, 0.71 | <0.001 |
| apoe.reg2 | 2.07 | 1.66, 2.58 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| ch | 1.05 | 0.72, 1.53 | 0.8 |
| dia | 1.06 | 0.61, 1.83 | 0.8 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 1.03 | 0.88, 1.21 | 0.7 |
| age | 1.84 | 1.56, 2.17 | <0.001 |
| sexe | 1.59 | 1.20, 2.11 | 0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.54 | 0.36, 0.79 | 0.002 |
| apoe.reg2 | 2.00 | 1.60, 2.50 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| ch | 1.10 | 0.75, 1.61 | 0.6 |
| dia | 1.08 | 0.62, 1.89 | 0.8 |
| imc | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.93 | 0.82, 1.05 | 0.2 | 0.98 | 0.86, 1.12 | 0.8 | 0.97 | 0.85, 1.11 | 0.6 | 0.97 | 0.85, 1.12 | 0.7 | 0.96 | 0.83, 1.12 | 0.6 | 1.03 | 0.88, 1.21 | 0.7 |
| age | 1.80 | 1.56, 2.10 | <0.001 | 1.86 | 1.60, 2.16 | <0.001 | 1.88 | 1.61, 2.20 | <0.001 | 1.90 | 1.62, 2.23 | <0.001 | 1.89 | 1.61, 2.23 | <0.001 | 1.84 | 1.56, 2.17 | <0.001 |
| sexe | 1.71 | 1.31, 2.23 | <0.001 | 1.74 | 1.32, 2.28 | <0.001 | 1.66 | 1.26, 2.20 | <0.001 | 1.66 | 1.26, 2.20 | <0.001 | 1.59 | 1.20, 2.11 | 0.001 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.94 | 0.70, 1.27 | 0.7 | 0.88 | 0.65, 1.20 | 0.4 | 0.76 | 0.55, 1.04 | 0.083 | 0.75 | 0.55, 1.04 | 0.082 | 0.80 | 0.58, 1.11 | 0.2 | |||
| niveau études mineurs | 0.88 | 0.63, 1.22 | 0.4 | 0.84 | 0.60, 1.17 | 0.3 | 0.49 | 0.33, 0.71 | <0.001 | 0.49 | 0.33, 0.71 | <0.001 | 0.54 | 0.36, 0.79 | 0.002 | |||
| apoe.reg2 | 2.19 | 1.77, 2.72 | <0.001 | 2.07 | 1.66, 2.58 | <0.001 | 2.07 | 1.66, 2.58 | <0.001 | 2.00 | 1.60, 2.50 | <0.001 | ||||||
| mmse | 0.89 | 0.87, 0.92 | <0.001 | 0.89 | 0.87, 0.92 | <0.001 | 0.89 | 0.87, 0.92 | <0.001 | |||||||||
| ch | 1.05 | 0.72, 1.53 | 0.8 | 1.10 | 0.75, 1.61 | 0.6 | ||||||||||||
| dia | 1.06 | 0.61, 1.83 | 0.8 | 1.08 | 0.62, 1.89 | 0.8 | ||||||||||||
| imc | 0.93 | 0.90, 0.96 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Tau en Continue
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.023 |
| age | 0.27 | 0.20, 0.34 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.04 | -0.03, 0.10 | 0.2 |
| age | 0.28 | 0.21, 0.34 | <0.001 |
| sexe | 0.22 | 0.10, 0.34 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 |
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.08 | 0.6 |
| age | 0.27 | 0.21, 0.34 | <0.001 |
| sexe | 0.23 | 0.11, 0.35 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.03 | -0.10, 0.16 | 0.7 |
| niveau études mineurs | 0.01 | -0.13, 0.16 | 0.9 |
| apoe.reg2 | 0.34 | 0.25, 0.43 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.20 | 0.09, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.09 | 0.5 |
| niveau études mineurs | -0.21 | -0.36, -0.06 | 0.006 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.09 | 0.6 |
| niveau études mineurs | -0.19 | -0.35, -0.04 | 0.013 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.03 | <0.001 |
| ch | -0.04 | -0.20, 0.11 | 0.6 |
| dia | -0.16 | -0.37, 0.05 | 0.13 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.26 | 0.19, 0.32 | <0.001 |
| sexe | 0.18 | 0.07, 0.30 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.11 | 0.7 |
| niveau études mineurs | -0.18 | -0.33, -0.03 | 0.022 |
| apoe.reg2 | 0.28 | 0.20, 0.37 | <0.001 |
| mmse | -0.05 | -0.06, -0.03 | <0.001 |
| ch | -0.04 | -0.20, 0.12 | 0.6 |
| dia | -0.15 | -0.36, 0.06 | 0.2 |
| imc | -0.01 | -0.02, 0.00 | 0.001 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.023 | 0.04 | -0.03, 0.10 | 0.2 | 0.01 | -0.05, 0.08 | 0.6 | 0.02 | -0.04, 0.08 | 0.5 | 0.01 | -0.05, 0.07 | 0.7 | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.27 | 0.20, 0.34 | <0.001 | 0.28 | 0.21, 0.34 | <0.001 | 0.27 | 0.21, 0.34 | <0.001 | 0.26 | 0.20, 0.32 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.26 | 0.19, 0.32 | <0.001 |
| sexe | 0.22 | 0.10, 0.34 | <0.001 | 0.23 | 0.11, 0.35 | <0.001 | 0.20 | 0.09, 0.32 | <0.001 | 0.20 | 0.08, 0.32 | <0.001 | 0.18 | 0.07, 0.30 | 0.002 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 | 0.03 | -0.10, 0.16 | 0.7 | -0.04 | -0.17, 0.09 | 0.5 | -0.04 | -0.17, 0.09 | 0.6 | -0.02 | -0.15, 0.11 | 0.7 | |||
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 | 0.01 | -0.13, 0.16 | 0.9 | -0.21 | -0.36, -0.06 | 0.006 | -0.19 | -0.35, -0.04 | 0.013 | -0.18 | -0.33, -0.03 | 0.022 | |||
| apoe.reg2 | 0.34 | 0.25, 0.43 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.28 | 0.20, 0.37 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.03 | <0.001 | -0.05 | -0.06, -0.03 | <0.001 | |||||||||
| ch | -0.04 | -0.20, 0.11 | 0.6 | -0.04 | -0.20, 0.12 | 0.6 | ||||||||||||
| dia | -0.16 | -0.37, 0.05 | 0.13 | -0.15 | -0.36, 0.06 | 0.2 | ||||||||||||
| imc | -0.01 | -0.02, 0.00 | 0.001 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.046 |
| age | 0.27 | 0.21, 0.34 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.28 | 0.22, 0.35 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.07, 0.20 | 0.3 |
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.01 | 0.14 |
| age | 0.28 | 0.22, 0.34 | <0.001 |
| sexe | 0.20 | 0.08, 0.31 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.04 | -0.09, 0.17 | 0.5 |
| niveau études mineurs | 0.01 | -0.13, 0.16 | 0.8 |
| apoe.reg2 | 0.33 | 0.25, 0.42 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.27 | 0.21, 0.33 | <0.001 |
| sexe | 0.17 | 0.06, 0.28 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.10 | 0.7 |
| niveau études mineurs | -0.22 | -0.37, -0.07 | 0.004 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.02 | -0.08, 0.04 | 0.5 |
| age | 0.27 | 0.21, 0.33 | <0.001 |
| sexe | 0.17 | 0.06, 0.28 | 0.003 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.11 | 0.8 |
| niveau études mineurs | -0.21 | -0.36, -0.06 | 0.006 |
| apoe.reg2 | 0.29 | 0.20, 0.37 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.16, 0.14 | >0.9 |
| dia | -0.16 | -0.38, 0.06 | 0.2 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.01 | -0.07, 0.05 | 0.7 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.16 | 0.05, 0.27 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.01 | -0.13, 0.12 | >0.9 |
| niveau études mineurs | -0.19 | -0.34, -0.04 | 0.011 |
| apoe.reg2 | 0.28 | 0.20, 0.36 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.16 | -0.38, 0.07 | 0.2 |
| imc | -0.01 | -0.02, 0.00 | <0.001 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.046 | -0.04 | -0.10, 0.02 | 0.2 | -0.04 | -0.10, 0.01 | 0.14 | -0.04 | -0.10, 0.02 | 0.2 | -0.02 | -0.08, 0.04 | 0.5 | -0.01 | -0.07, 0.05 | 0.7 |
| age | 0.27 | 0.21, 0.34 | <0.001 | 0.28 | 0.22, 0.35 | <0.001 | 0.28 | 0.22, 0.34 | <0.001 | 0.27 | 0.21, 0.33 | <0.001 | 0.27 | 0.21, 0.33 | <0.001 | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 | 0.20 | 0.08, 0.31 | <0.001 | 0.17 | 0.06, 0.28 | 0.002 | 0.17 | 0.06, 0.28 | 0.003 | 0.16 | 0.05, 0.27 | 0.005 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.07, 0.20 | 0.3 | 0.04 | -0.09, 0.17 | 0.5 | -0.02 | -0.15, 0.10 | 0.7 | -0.02 | -0.15, 0.11 | 0.8 | -0.01 | -0.13, 0.12 | >0.9 | |||
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 | 0.01 | -0.13, 0.16 | 0.8 | -0.22 | -0.37, -0.07 | 0.004 | -0.21 | -0.36, -0.06 | 0.006 | -0.19 | -0.34, -0.04 | 0.011 | |||
| apoe.reg2 | 0.33 | 0.25, 0.42 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.29 | 0.20, 0.37 | <0.001 | 0.28 | 0.20, 0.36 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | -0.01 | -0.16, 0.14 | >0.9 | 0.00 | -0.15, 0.15 | >0.9 | ||||||||||||
| dia | -0.16 | -0.38, 0.06 | 0.2 | -0.16 | -0.38, 0.07 | 0.2 | ||||||||||||
| imc | -0.01 | -0.02, 0.00 | <0.001 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Ptau
Tableau de fréquence
| ptau elevé (N=495) | ptau normal (N=481) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.531 (8.008) | 67.744 (9.346) | 69.665 (8.893) | |
| - Range | 50.000 - 89.000 | 42.000 - 88.000 | 42.000 - 89.000 | |
| Sexe | 0.006 | |||
| - Femme | 290 (58.6%) | 240 (49.9%) | 530 (54.3%) | |
| - Homme | 205 (41.4%) | 241 (50.1%) | 446 (45.7%) | |
| Glucose | 0.318 | |||
| - Mean (SD) | 5.701 (1.533) | 5.809 (1.834) | 5.754 (1.688) | |
| - Range | 0.920 - 20.900 | 0.720 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.146 | |||
| - Mean (SD) | 0.936 (0.333) | 0.967 (0.345) | 0.951 (0.339) | |
| - Range | 0.340 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.019 | |||
| - Mean (SD) | 2.155 (0.517) | 2.078 (0.501) | 2.117 (0.510) | |
| - Range | 1.030 - 6.640 | 0.820 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | < 0.001 | |||
| - Mean (SD) | 0.611 (0.161) | 0.573 (0.157) | 0.593 (0.160) | |
| - Range | 0.210 - 1.100 | 0.240 - 1.590 | 0.210 - 1.590 | |
| Cholesterol ldl | 0.027 | |||
| - Mean (SD) | 1.348 (0.414) | 1.292 (0.375) | 1.321 (0.396) | |
| - Range | 0.360 - 2.970 | 0.200 - 2.380 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 219 (44.2%) | 321 (66.7%) | 540 (55.3%) | |
| - 1 | 213 (43.0%) | 139 (28.9%) | 352 (36.1%) | |
| - 2 | 63 (12.7%) | 21 (4.4%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.477 (5.299) | 23.528 (4.846) | 22.488 (5.181) | |
| - Range | 6.000 - 30.000 | 4.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.153 | |||
| - 0 | 413 (83.4%) | 417 (86.7%) | 830 (85.0%) | |
| - 1 | 82 (16.6%) | 64 (13.3%) | 146 (15.0%) | |
| Traitement Diabete | 0.081 | |||
| - 0 | 467 (94.3%) | 440 (91.5%) | 907 (92.9%) | |
| - 1 | 28 (5.7%) | 41 (8.5%) | 69 (7.1%) | |
| Niveau d’étude | 0.734 | |||
| - N-Miss | 33 | 33 | 66 | |
| - études supérieurs | 169 (36.6%) | 171 (38.2%) | 340 (37.4%) | |
| - niveau études intermédiaires | 165 (35.7%) | 163 (36.4%) | 328 (36.0%) | |
| - niveau études mineurs | 128 (27.7%) | 114 (25.4%) | 242 (26.6%) |
Ptau en Catégorie
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.20 | 1.06, 1.38 | 0.006 |
| age | 1.72 | 1.48, 2.00 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.14 | 1.00, 1.32 | 0.060 |
| age | 1.75 | 1.50, 2.04 | <0.001 |
| sexe | 1.42 | 1.09, 1.87 | 0.010 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.20 | 0.89, 1.62 | 0.2 |
| niveau études mineurs | 1.09 | 0.79, 1.51 | 0.6 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.27 | 0.2 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.49 | 1.13, 1.97 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.13 | 0.83, 1.54 | 0.4 |
| niveau études mineurs | 1.04 | 0.75, 1.46 | 0.8 |
| apoe.reg2 | 2.01 | 1.64, 2.49 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.96, 1.27 | 0.2 |
| age | 1.77 | 1.51, 2.08 | <0.001 |
| sexe | 1.43 | 1.08, 1.90 | 0.013 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.74, 1.38 | >0.9 |
| niveau études mineurs | 0.74 | 0.51, 1.07 | 0.11 |
| apoe.reg2 | 1.90 | 1.54, 2.35 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.28 | 0.2 |
| age | 1.76 | 1.50, 2.07 | <0.001 |
| sexe | 1.41 | 1.06, 1.87 | 0.017 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.74, 1.39 | >0.9 |
| niveau études mineurs | 0.75 | 0.52, 1.09 | 0.13 |
| apoe.reg2 | 1.89 | 1.53, 2.34 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.18 | 0.81, 1.73 | 0.4 |
| dia | 0.75 | 0.45, 1.24 | 0.3 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.07 | 0.93, 1.24 | 0.3 |
| age | 1.72 | 1.46, 2.03 | <0.001 |
| sexe | 1.34 | 1.01, 1.79 | 0.044 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.07 | 0.78, 1.48 | 0.7 |
| niveau études mineurs | 0.83 | 0.57, 1.20 | 0.3 |
| apoe.reg2 | 1.86 | 1.50, 2.31 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.21 | 0.82, 1.77 | 0.3 |
| dia | 0.82 | 0.49, 1.36 | 0.4 |
| imc | 0.94 | 0.91, 0.97 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.20 | 1.06, 1.38 | 0.006 | 1.14 | 1.00, 1.32 | 0.060 | 1.10 | 0.95, 1.27 | 0.2 | 1.10 | 0.96, 1.27 | 0.2 | 1.10 | 0.95, 1.28 | 0.2 | 1.07 | 0.93, 1.24 | 0.3 |
| age | 1.72 | 1.48, 2.00 | <0.001 | 1.75 | 1.50, 2.04 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.77 | 1.51, 2.08 | <0.001 | 1.76 | 1.50, 2.07 | <0.001 | 1.72 | 1.46, 2.03 | <0.001 |
| sexe | 1.42 | 1.09, 1.87 | 0.010 | 1.49 | 1.13, 1.97 | 0.005 | 1.43 | 1.08, 1.90 | 0.013 | 1.41 | 1.06, 1.87 | 0.017 | 1.34 | 1.01, 1.79 | 0.044 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.20 | 0.89, 1.62 | 0.2 | 1.13 | 0.83, 1.54 | 0.4 | 1.01 | 0.74, 1.38 | >0.9 | 1.01 | 0.74, 1.39 | >0.9 | 1.07 | 0.78, 1.48 | 0.7 | |||
| niveau études mineurs | 1.09 | 0.79, 1.51 | 0.6 | 1.04 | 0.75, 1.46 | 0.8 | 0.74 | 0.51, 1.07 | 0.11 | 0.75 | 0.52, 1.09 | 0.13 | 0.83 | 0.57, 1.20 | 0.3 | |||
| apoe.reg2 | 2.01 | 1.64, 2.49 | <0.001 | 1.90 | 1.54, 2.35 | <0.001 | 1.89 | 1.53, 2.34 | <0.001 | 1.86 | 1.50, 2.31 | <0.001 | ||||||
| mmse | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | |||||||||
| ch | 1.18 | 0.81, 1.73 | 0.4 | 1.21 | 0.82, 1.77 | 0.3 | ||||||||||||
| dia | 0.75 | 0.45, 1.24 | 0.3 | 0.82 | 0.49, 1.36 | 0.4 | ||||||||||||
| imc | 0.94 | 0.91, 0.97 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.86 | 0.75, 0.98 | 0.023 |
| age | 1.71 | 1.48, 1.98 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 2
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.89 | 0.78, 1.02 | 0.093 |
| age | 1.75 | 1.51, 2.04 | <0.001 |
| sexe | 1.45 | 1.12, 1.88 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.17 | 0.87, 1.57 | 0.3 |
| niveau études mineurs | 1.06 | 0.77, 1.47 | 0.7 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 3
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.88 | 0.77, 1.00 | 0.062 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.46 | 1.12, 1.91 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.11 | 0.82, 1.51 | 0.5 |
| niveau études mineurs | 1.02 | 0.74, 1.43 | 0.9 |
| apoe.reg2 | 2.04 | 1.66, 2.51 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 4
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.88 | 0.77, 1.01 | 0.066 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.41 | 1.07, 1.84 | 0.013 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.75, 1.38 | >0.9 |
| niveau études mineurs | 0.72 | 0.50, 1.03 | 0.077 |
| apoe.reg2 | 1.94 | 1.58, 2.40 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 5
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.90 | 0.78, 1.05 | 0.2 |
| age | 1.75 | 1.50, 2.05 | <0.001 |
| sexe | 1.40 | 1.07, 1.84 | 0.014 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.02 | 0.75, 1.38 | >0.9 |
| niveau études mineurs | 0.72 | 0.50, 1.03 | 0.076 |
| apoe.reg2 | 1.92 | 1.56, 2.38 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.25 | 0.87, 1.81 | 0.2 |
| dia | 0.77 | 0.45, 1.32 | 0.3 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Modèle 6
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.82, 1.11 | 0.5 |
| age | 1.70 | 1.45, 2.00 | <0.001 |
| sexe | 1.34 | 1.02, 1.77 | 0.034 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.07 | 0.79, 1.47 | 0.7 |
| niveau études mineurs | 0.79 | 0.55, 1.15 | 0.2 |
| apoe.reg2 | 1.86 | 1.51, 2.31 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.30 | 0.90, 1.89 | 0.2 |
| dia | 0.79 | 0.46, 1.36 | 0.4 |
| imc | 0.94 | 0.91, 0.97 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.86 | 0.75, 0.98 | 0.023 | 0.89 | 0.78, 1.02 | 0.093 | 0.88 | 0.77, 1.00 | 0.062 | 0.88 | 0.77, 1.01 | 0.066 | 0.90 | 0.78, 1.05 | 0.2 | 0.95 | 0.82, 1.11 | 0.5 |
| age | 1.71 | 1.48, 1.98 | <0.001 | 1.75 | 1.51, 2.04 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.75 | 1.50, 2.05 | <0.001 | 1.70 | 1.45, 2.00 | <0.001 |
| sexe | 1.45 | 1.12, 1.88 | 0.005 | 1.46 | 1.12, 1.91 | 0.005 | 1.41 | 1.07, 1.84 | 0.013 | 1.40 | 1.07, 1.84 | 0.014 | 1.34 | 1.02, 1.77 | 0.034 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.17 | 0.87, 1.57 | 0.3 | 1.11 | 0.82, 1.51 | 0.5 | 1.01 | 0.75, 1.38 | >0.9 | 1.02 | 0.75, 1.38 | >0.9 | 1.07 | 0.79, 1.47 | 0.7 | |||
| niveau études mineurs | 1.06 | 0.77, 1.47 | 0.7 | 1.02 | 0.74, 1.43 | 0.9 | 0.72 | 0.50, 1.03 | 0.077 | 0.72 | 0.50, 1.03 | 0.076 | 0.79 | 0.55, 1.15 | 0.2 | |||
| apoe.reg2 | 2.04 | 1.66, 2.51 | <0.001 | 1.94 | 1.58, 2.40 | <0.001 | 1.92 | 1.56, 2.38 | <0.001 | 1.86 | 1.51, 2.31 | <0.001 | ||||||
| mmse | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | |||||||||
| ch | 1.25 | 0.87, 1.81 | 0.2 | 1.30 | 0.90, 1.89 | 0.2 | ||||||||||||
| dia | 0.77 | 0.45, 1.32 | 0.3 | 0.79 | 0.46, 1.36 | 0.4 | ||||||||||||
| imc | 0.94 | 0.91, 0.97 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
Ptau en Continue
Association avec le cholestérol
## [1] "N = 1009"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.018 |
| age | 0.26 | 0.19, 0.33 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.05 | -0.02, 0.11 | 0.14 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.18 | 0.05, 0.30 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 |
| niveau études mineurs | 0.06 | -0.09, 0.21 | 0.5 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.09 | 0.4 |
| age | 0.26 | 0.19, 0.33 | <0.001 |
| sexe | 0.19 | 0.07, 0.31 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.02 | -0.11, 0.16 | 0.7 |
| niveau études mineurs | 0.03 | -0.11, 0.18 | 0.7 |
| apoe.reg2 | 0.35 | 0.26, 0.44 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.17 | 0.05, 0.29 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.03 | -0.16, 0.10 | 0.7 |
| niveau études mineurs | -0.13 | -0.29, 0.02 | 0.087 |
| apoe.reg2 | 0.32 | 0.23, 0.40 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.03 | -0.16, 0.11 | 0.7 |
| niveau études mineurs | -0.12 | -0.28, 0.04 | 0.13 |
| apoe.reg2 | 0.31 | 0.23, 0.40 | <0.001 |
| mmse | -0.03 | -0.05, -0.02 | <0.001 |
| ch | 0.01 | -0.15, 0.17 | >0.9 |
| dia | -0.16 | -0.37, 0.06 | 0.2 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.15 | 0.03, 0.27 | 0.014 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.01 | -0.15, 0.12 | 0.8 |
| niveau études mineurs | -0.11 | -0.26, 0.05 | 0.2 |
| apoe.reg2 | 0.31 | 0.22, 0.39 | <0.001 |
| mmse | -0.03 | -0.05, -0.02 | <0.001 |
| ch | 0.01 | -0.15, 0.17 | >0.9 |
| dia | -0.14 | -0.36, 0.07 | 0.2 |
| imc | -0.01 | -0.01, 0.00 | 0.009 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.018 | 0.05 | -0.02, 0.11 | 0.14 | 0.02 | -0.04, 0.09 | 0.4 | 0.03 | -0.03, 0.09 | 0.4 | 0.02 | -0.04, 0.08 | 0.5 | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.26 | 0.19, 0.33 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.26 | 0.19, 0.33 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.18 | 0.05, 0.30 | 0.005 | 0.19 | 0.07, 0.31 | 0.002 | 0.17 | 0.05, 0.29 | 0.005 | 0.16 | 0.04, 0.28 | 0.008 | 0.15 | 0.03, 0.27 | 0.014 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 | 0.02 | -0.11, 0.16 | 0.7 | -0.03 | -0.16, 0.10 | 0.7 | -0.03 | -0.16, 0.11 | 0.7 | -0.01 | -0.15, 0.12 | 0.8 | |||
| niveau études mineurs | 0.06 | -0.09, 0.21 | 0.5 | 0.03 | -0.11, 0.18 | 0.7 | -0.13 | -0.29, 0.02 | 0.087 | -0.12 | -0.28, 0.04 | 0.13 | -0.11 | -0.26, 0.05 | 0.2 | |||
| apoe.reg2 | 0.35 | 0.26, 0.44 | <0.001 | 0.32 | 0.23, 0.40 | <0.001 | 0.31 | 0.23, 0.40 | <0.001 | 0.31 | 0.22, 0.39 | <0.001 | ||||||
| mmse | -0.04 | -0.05, -0.02 | <0.001 | -0.03 | -0.05, -0.02 | <0.001 | -0.03 | -0.05, -0.02 | <0.001 | |||||||||
| ch | 0.01 | -0.15, 0.17 | >0.9 | 0.01 | -0.15, 0.17 | >0.9 | ||||||||||||
| dia | -0.16 | -0.37, 0.06 | 0.2 | -0.14 | -0.36, 0.07 | 0.2 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.009 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
Association avec le glucose
## [1] "N = 1038"Modèle 1
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.039 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 2
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.13 |
| age | 0.27 | 0.20, 0.33 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.08 | -0.06, 0.21 | 0.3 |
| niveau études mineurs | 0.06 | -0.08, 0.21 | 0.4 |
| 1 CI = Confidence Interval | |||
Modèle 3
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.087 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.16 | 0.04, 0.27 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.05 | -0.08, 0.18 | 0.4 |
| niveau études mineurs | 0.05 | -0.10, 0.19 | 0.5 |
| apoe.reg2 | 0.34 | 0.25, 0.42 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 4
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.10 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.14 | 0.02, 0.25 | 0.017 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.00 | -0.13, 0.13 | >0.9 |
| niveau études mineurs | -0.13 | -0.28, 0.02 | 0.094 |
| apoe.reg2 | 0.30 | 0.22, 0.39 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| 1 CI = Confidence Interval | |||
Modèle 5
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.03 | 0.3 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.14 | 0.02, 0.25 | 0.018 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.01 | -0.12, 0.13 | >0.9 |
| niveau études mineurs | -0.13 | -0.28, 0.03 | 0.11 |
| apoe.reg2 | 0.30 | 0.21, 0.39 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| ch | 0.04 | -0.11, 0.19 | 0.6 |
| dia | -0.14 | -0.37, 0.09 | 0.2 |
| 1 CI = Confidence Interval | |||
Modèle 6
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.13 | 0.01, 0.24 | 0.030 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.02 | -0.11, 0.15 | 0.8 |
| niveau études mineurs | -0.11 | -0.26, 0.04 | 0.2 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| ch | 0.04 | -0.11, 0.20 | 0.6 |
| dia | -0.14 | -0.36, 0.09 | 0.2 |
| imc | -0.01 | -0.01, 0.00 | 0.005 |
| 1 CI = Confidence Interval | |||
Tableau récapitulatif
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.039 | -0.05 | -0.10, 0.01 | 0.13 | -0.05 | -0.11, 0.01 | 0.087 | -0.05 | -0.10, 0.01 | 0.10 | -0.03 | -0.09, 0.03 | 0.3 | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.26 | 0.20, 0.32 | <0.001 | 0.27 | 0.20, 0.33 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 | 0.16 | 0.04, 0.27 | 0.008 | 0.14 | 0.02, 0.25 | 0.017 | 0.14 | 0.02, 0.25 | 0.018 | 0.13 | 0.01, 0.24 | 0.030 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.08 | -0.06, 0.21 | 0.3 | 0.05 | -0.08, 0.18 | 0.4 | 0.00 | -0.13, 0.13 | >0.9 | 0.01 | -0.12, 0.13 | >0.9 | 0.02 | -0.11, 0.15 | 0.8 | |||
| niveau études mineurs | 0.06 | -0.08, 0.21 | 0.4 | 0.05 | -0.10, 0.19 | 0.5 | -0.13 | -0.28, 0.02 | 0.094 | -0.13 | -0.28, 0.03 | 0.11 | -0.11 | -0.26, 0.04 | 0.2 | |||
| apoe.reg2 | 0.34 | 0.25, 0.42 | <0.001 | 0.30 | 0.22, 0.39 | <0.001 | 0.30 | 0.21, 0.39 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | ||||||
| mmse | -0.04 | -0.05, -0.02 | <0.001 | -0.04 | -0.05, -0.02 | <0.001 | -0.04 | -0.05, -0.02 | <0.001 | |||||||||
| ch | 0.04 | -0.11, 0.19 | 0.6 | 0.04 | -0.11, 0.20 | 0.6 | ||||||||||||
| dia | -0.14 | -0.37, 0.09 | 0.2 | -0.14 | -0.36, 0.09 | 0.2 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.005 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "data_export = data.frame(abeta42_continu = data2$abeta42_,\n abeta_42_modalite = data2$abeta42t2,\n tau_continu = data2$tau_,\n tau_modalite = data2$taut2,\n glucose = data2$glucose_jeun,\n glucose_std = scale(data2$glucose_jeun),\n triglycerides = data2$triglycerides,\n triglycerides_std = scale(data2$triglycerides),\n cholesterol_total = data2$cholesterol_total,\n cholesterol_total_std = scale(data2$cholesterol_total),\n cholesterol_hdl = data2$cholesterol_hdl,\n cholesterol_hdl.std = scale(data2$cholesterol_hdl),\n cholesterol_ldl = data2$cholesterol_ldl,\n cholesterol_ldl.std = scale(data2$cholesterol_ldl),\n education = data2$niveau_etude_reg,\n age = data2$age,\n sexe = data2$sexe_reg,\n apoe = data2$apoe,\n traitement_chol = data2$ch,\n traitement_dia = data2$dia,\n mmse = data2$mmse,\n imc = data2$imc\n )"